CCOI

CENTER FOR CLINICAL OBSERVATIONAL INVESTIGATIONS

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AgingResearchBiobank

MOST: Multicenter Osteoarthritis Study

Organization: National Institute of Aging

Description

MOST (Multicenter Osteoarthritis Study) is a multi-center longitudinal, prospective, observational study of a cohort of Americans aged 50-79 years with knee osteroarthritis (OA) or at increased risk of developing the knee OA. The main purpose of the study is to investigate the etiology of the OA and opportunities for its prevention and treatment. The study has been operational since 2001 and funded by National Institute on Aging (NIA). Study participants attended baseline examination and follow-up assessments for physical function and performance evaluations.

Key Information

Dataset Contents
Study Date Span	2003-2018
Participant Count	4,551
Data Collection Status	Complete
Dataset Type	Medical Records, MRI and X-Ray
Region	United States
Age	50 - 79

Dataset Contents

Study Date Span

2003-2018

Participant Count

4,551

Data Collection Status

Complete

Dataset Type

Medical Records, MRI and X-Ray

Region

United States

Age

50 - 79

Access & Availability
Native Data Structure	Custom
Data Identifiability	De-identified

Access & Availability

Native Data Structure

Custom

Data Identifiability

De-identified

References and Resources:

Homepage:https://agingresearchbiobank.nia.nih.gov/studies/most/details

Data Dictionary:

Downloadable document is available from the study homepage

Notable Publications:

MOST Publications

Last updated Jul 16, 2025