CCOI

CENTER FOR CLINICAL OBSERVATIONAL INVESTIGATIONS

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AgingResearchBiobank

SOF: Study of Osteoporotic Fractures

Organization: National Institute of Aging

Description

SOF (Study of Osteoporotic Fractures) is a multi-center prospective observational study of a cohort of 10,366 women aged 65 or older who were recruited from four metropolitan areas in the United States: Baltimore, Pittsburgh, Minneapolis and Portland. The study was funded by National Institute on Aging (NIA) and operational from 1986 until 2017. The primary purpose of SOF has been to describe the risk factors for osteoporotic fractures. Participants were identified from community-based listings, such as memberships of large health maintenance organizations, and attended a series of clinical visits and follow-up assessments for various physical and mental evaluations.

Key Information

Dataset Contents
Study Date Span 1986-2009
Participant Count 10,366 (9704 enrolled at baseline. 662 African American women were enrolled in a new cohort at visit 6. The tables in basic statistics represent the original cohort only).
Data Collection Status Complete
Dataset Type Medical Records, Survey
Region United States
Age 65 or above
Access & Availability
Native Data Structure OMOP
Data Identifiability De-identified

Data Dictionary:

  • Downloadable document is available from the study homepage

Notable Publications:

Last updated Jul 23, 2025